Clearing tau pathology with Abeta immunotherapy--reversible and irreversible stages revealed |
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Authors: | Hutton Michael McGowan Eileen |
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Affiliation: | Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA. |
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Abstract: | The report by Oddo and colleagues in this issue of Neuron demonstrates for the first time that clearance of amyloid also results in the removal of early-stage tau pathology in mice that develop both amyloid plaques and neurofibrillary tangles (NFT), the two hallmark lesions of Alzheimer's disease (AD). This result supports a primary role for Abeta in AD etiology. |
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