Changes in insulin receptor,hexokinase and NADPH producing enzymes in Choroid plexus during experimental diabetes |
| |
Authors: | Mansoor A. Ansari Biharil Gupta Najma Z. Baquer |
| |
Affiliation: | (1) Hormone and Drug Research Laboratory, School of Life Sciences, Jawaharlal Nehru University, 110 067 New Delhi, India |
| |
Abstract: | The activities of insulin receptor and the enzymes hexokinase (EC 2.7.1.1) and NADP-dependent malic enzyme (EC1.1.1.40), glucose 6-phosphate dehydrogenase (EC 1.1.1.49) and isocitrate dehydrogenase (EC 1.1.1.42) were measured in rat choroid plexus in alloxan induced diabetes. A significant decrease was observed in the activities of all the enzymes except isocitrate dehydrogenase and also the choroid plexus insulin receptor activity was decreased. A reversal of the efect was observed with insulin administration to diabetic rats. It may be concluded that the enzymes of choroid plexus together with insulin receptor are directly controlled by-the concentration of insulin. |
| |
Keywords: | Choroid plexus diabetes hexokinase isocitrate dehydrogenase (NADP) malate dehydrogenase (NADP) glucose 6-phosphate dehydrogenase |
本文献已被 SpringerLink 等数据库收录! |