Variation among mouse strains in responsiveness to migration inhibitory factor. |
| |
| Authors: | A Tagliabue R B Herberman J L McCoy |
| |
| Affiliation: | Laboratory of Immunodiagnosis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20014 U.S.A. |
| |
| Abstract: | Mineral oil-induced peritoneal exudate cells (PEC) from 10 different inbred mouse strains were tested for their responses to macrophage migration inhibitory factor (MIF). PEC from 5 out of 10 mouse strains responded to MIF, PEC from BALB/c mice showed an intermediate responsiveness, and PEC from A/J, C3H/HeJ, CBA/N, and C57BL/10ScCR mice were refractory to MIF. MIF responsiveness was not linked to the H-2 complex. However, a possible link between responsiveness to LPS and MIF was suggested, since the mouse strains not responding to MIF were previously reported to be deficient for responses to LPS. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
