α/β Hydrolase fold enzymes: the family keeps growing |
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Authors: | Marco Nardini Bauke W Dijkstra |
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Affiliation: | Laboratory of Biophysical Chemistry and BIOSON Research Institute, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands |
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Abstract: | The α/β hydrolase fold is a typical example of a tertiary fold adopted by proteins that have no obvious sequence similarity, but nevertheless, in the course of evolution, diverged from a common ancestor. Recently solved structures demonstrate a considerably increased variability in fold architecture and substrate specificity, necessitating the redefinition of the minimal features that distinguish the family. |
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Keywords: | α /β hydrolase fold Fold variability Fold architecture Sequence similarity Tertiary fold Substrate specificity Fold evolution |
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