Invasive Geotrichum clavatum Fungal Infection in an Acute Myeloid Leukaemia Patient: A Case Report and Review |
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Authors: | Vincent Camus Marie-Laure Thibault Marion David Gilles Gargala Patricia Compagnon Fabien Lamoureux Christophe Girault Jean-Baptiste Michot Aspasia Stamatoullas Hélène Lanic Fabrice Jardin Pascal Lenain Hervé Tilly Stéphane Leprêtre |
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Institution: | 1. Department of Hematology, Centre Henri Becquerel, rue d’Amiens, 76038, Rouen, France 2. Intensive Care Unit, Charles Nicolle University Hospital, Rouen, France 3. Department of Biology, Centre Henri Becquerel, Rouen, France 4. Department of Mycology-Parasitology, Charles Nicolle University Hospital, Rouen, France 5. Department of Pharmacology, Charles Nicolle University Hospital, Rouen, France
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Abstract: | Invasive Geotrichum clavatum fungal infections are extremely rare and unusual, occurring nearly exclusively in patients experiencing prolonged neutropenia during the treatment for acute myeloid leukaemia. Several groups of cases of fatal G. clavatum infection were reported in France between 2011 and 2012, but the ecological niche has not yet been identified. We report a case of a 32-year-old patient with acute myeloid leukaemia who developed G. clavatum sepsis with primary peritonitis, hepatic nodular lesions, and multivisceral failure during aplasia after induction followed by salvage chemotherapy. He was treated with voriconazole and is still alive 1 year after with controlled disease. We then discuss the epidemiological, clinical, and therapeutic features of these serious fungal infections compared to the published data. |
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