XY sex reversal syndrome in the mare: clinical and behavioral studies,H-Y phenotype |
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Authors: | Marijo G. Kent Robert N. Shoffner Allan Hunter Keith O. Elliston Wesley Schroder Elizabeth Tolley Stephen S. Wachtel |
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Affiliation: | (1) Department of Obstetrics and Gynecology, University of Tennessee, 853 Jefferson, 38163 Memphis, TN, USA;(2) University of Minnesota College of Veterinary Medicine, 55108 St. Paul, MN, USA;(3) Minnesota Equine Practitioners, 55359 Maple Plain, MN, USA;(4) Department of Biostatistics and Epidemiology, University of Tennessee, 38163 Memphis, TN, USA;(5) Center for Reproductive Biology, 38017 Collierville, TN, USA |
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Abstract: | Summary An inherited genetic disorder causes XY embryos of the horse to develop as mares. On the basis of our study of 38 such mares, we have identified four grades or classes of XY sex reversal according to this scheme: class I, nearly normal female, of which some are fertile; class II, female with gonadal dysgenesis, normal mullerian development; calss III, intersex mare with gonadal dysgenesis, abnormal mullerian development, enlarged clitoris; class IV, virilized intersex characterized by high levels of testosterone. In general, class I and calss II mares were typed H-Y antigen-negative whereas class III and class IV mares were typed H-Y antigen-positive. |
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