Canonical protein splicing of a class 1 intein that has a class 3 noncanonical sequence motif |
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| Authors: | Reitter Julie N Mills Kenneth V |
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| Affiliation: | Department of Chemistry, College of the Holy Cross, Worcester, MA 01610, USA. |
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| Abstract: | A Thermobifida fusca intein has two characteristics of class 3 inteins: a noncontiguous covariant Trp-Cys-Thr triplet and a Ser flanking its C terminus. However, it has Cys at position one, characteristic of class 1 inteins. Splicing does not require the internal Cys, which may instead coordinate the active site. Therefore, the intein is class 1. |
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