Adaptive thermogenesis in Brandt's vole (Lasiopodomys brandti) during cold and warm acclimation |
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| Authors: | Jin-Song Liu Ming Yang Ru-Yong Sun De-Hua Wang |
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| Institution: | 1. State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Science, Beijing 100101, China;2. Department of Physiology, Basic Medical College, Inner Mongolia Medical University, Huhehaote 010110, China;3. Graduate School of the Chinese Academy of Sciences, Yuquan Lu, Beijing 100049, China;1. Department of Brain and Cognitive Sciences, College of Natural Sciences, Seoul National University, Seoul, Republic of Korea;2. Department of Psychology, Duksung Women''s University, Seoul, Republic of Korea;3. Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea;4. Department of Psychology, Chung-Ang University, Seoul, Republic of Korea;5. Department of Psychiatry, Seoul National University College of Medicine, Seoul, Republic of Korea;1. Department of Biology, University of South Dakota, Vermillion, SD 57069, USA;2. Department of Biology, University of Western Ontario, London, ON, Canada, N6A 5B7 |
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| Abstract: | Brandt's voles (Lasiopodomys brandti) exposed to cold (5±1 °C) or warm (23±1 °C) showed some physiological and biochemical variations which might be important in adaptation to their environments. Cold acclimation induced increases in resting metabolic rate (RMR) and the serum triiodothyronine (T3) level, the state-4 respiration of liver and muscle mitochondria were activated after 7 days when animals exposed to cold, and the activity of cytochrome c oxidase (COX) of liver and muscle mitochondria tended to rise with cold exposure. RMR and T3 level decreased during warm acclimation. The state-4 respiration of liver mitochondria declined after 3 days and muscle after 7 days when animals exposed to warm, and the activities of COX of liver and muscle mitochondria tended to decrease with warm acclimation. The cold activation of liver and muscle mitochondrial respiration (regulated by T3) was one of the cytological mechanisms of elevating RMR. Both state-4 respiration and COX activity of brown adipose tissue (BAT) mitochondria increased significantly during cold acclimation and decreased markedly after acclimated to warm. The uncoupling protein 1 (UCP1) contents in BAT increased after exposure to cold and decreased after warm acclimation. Nonshivering thermogenesis (NST) plays an important role in the process of thermoregulation under cold acclimation for Brandt's voles. Changes in thermogenesis is a important way to cold adaptation for Brandt's voles in natural environments. |
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