THE EFFECT OF ELECTRICAL STIMULATION UPON THE ACCUMULATION OF ADENOSINE 3',5'-PHOSPHATE IN ISOLATED CEREBRAL TISSUE |
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| Authors: | S Kakiuchi T W Rall H McIlwain |
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| Institution: | Department of Pharmacology, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106 and Department of Biochemistry Institute of Psychiatry (British Postgraduate Medical Federation, University of London) De Crespigny Park, London S.E.5 |
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| Abstract: | The application of electrical pulses to slices of guinea pig cerebral cortex led to an increase in the levels of adenosine 3′,5′-phosphate (cyclic 3′,5′-AMP) of more than 11-fold within 10 min. This effect of electrical pulses was severely reduced in the presence of theophylline. Cyclic 3′,5′-AMP accumulation in slices was increased in the presence of norepinephrine and histamine about 1·5-fold and six-fold, respectively; the effect of electrical pulses was augmented in the presence of maximal amounts of either amine. For these and other reasons, the accumulation of cyclic 3′,5′-AMP induced by electrical stimulation cannot be ascribed to the release and action of either histamine or norepinephrine. |
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