Analysis of proteomic profiles and functional properties of human peripheral blood myeloid dendritic cells,monocyte-derived dendritic cells and the dendritic cell-like KG-1 cells reveals distinct characteristics |
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| Authors: | Claire Horlock Farouk Shakib Jafar Mahdavi Nick S Jones Herb F Sewell Amir M Ghaemmaghami |
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| Affiliation: | (1) Immunity and Inflammation, Institute of Infection, School of Molecular Medical Sciences, The University of Nottingham, NG7 2UH Nottingham, UK;(2) Division of Otorhinolaryngology, School of Medical and Surgical Sciences, The University of Nottingham, NG7 2UH Nottingham, UK |
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| Abstract: | Background Dendritic cells (DCs) are specialized antigen presenting cells that play a pivotal role in bridging innate and adaptive immune responses. Given the scarcity of peripheral blood myeloid dendritic cells (mDCs) investigators have used different model systems for studying DC biology. Monocyte-derived dendritic cells (moDCs) and KG-1 cells are routinely used as mDC models, but a thorough comparison of these cells has not yet been carried out, particularly in relation to their proteomes. We therefore sought to run a comparative study of the proteomes and functional properties of these cells. |
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