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Inhibition of cartilage breakdown by isothiazolones |
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| Authors: | Stephen W Wright Joseph J Petraitis Matthew M Abelman Lori L Bostrom Ronald L Corbett Alicia M Green Rachel M Kindt Susan R Sherk Ronald L Magolda |
| Institution: | The Du Pont Merck Pharmaceutical Company, Du Pont Experimental Station, Wilmington, Delaware 19880 USA |
| Abstract: | Isothiazolones and isoselenazolones have been found to inhibit IL-1β induced breakdown of bovine nasal cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds represent a novel, non-peptide lead series approach to the mediation of the chronic cartilage breakdown associated with arthritic disease. |
| Keywords: | Isothiazolone isoselenazolone bovine nasal cartilage organ culture assay arthritis |
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