The influence of dissolved oxygen tension on the synthesis of the antibiotic difficidin by bacillus subtilis |
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Authors: | Suphantharika M Ison A P Lilly M D Buckland B C |
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Affiliation: | The Advanced Centre for Biochemical Engineering, Department of Chemical and Biochemical Engineering, University College London, Torrington Place, London WC1E 7JE, United Kingdom. |
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Abstract: | The antibiotic, difficidin, and its hydroxylated derivative oxydifficidin, were synthesized by cultures of Bacillus subtilis grown on a complex medium. Maximum titers of about 200 and 130 mg/L, respectively, were obtained. In fermentations where the dissolved oxygen tension (DOT) was controlled, the maximum specific growth rate was only reduced below 5% air saturation. DOT had little effect on the volumetric rateof synthesis of oxydifficidin but greatly influenced the rate for difficidin, which was reduced at DOT values below 40% air saturation. (c) 1994 John Wiley & Sons, Inc. |
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Keywords: | difficidin oxydifficidin Bacillus subtilis dissolved oxygen tension |
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