Gold nanoparticles functionalised by Gd-complex of DTPA-bis(amide) conjugate of glutathione as an MRI contrast agent |
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Authors: | Park Ji-Ae Reddy Pattubala A N Kim Hee-Kyung Kim In-Sung Kim Gab-Chul Chang Yongmin Kim Tae-Jeong |
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Affiliation: | Department of Medical & Biological Engineering, Kyungpook National University, Daegu, Republic of Korea. |
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Abstract: | The work is directed toward the synthesis of gold nanoparticles (Au NPs) coated with paramagnetic Gd-complex of DTPA-bis(amide) conjugate of glutathione (GdL) for use as a highly efficient MRI contrast agent. Well-dispersed spherical Au NPs coated with gadolinium complexes, abbreviated as Au@GdL, have been obtained; the mean size of Au@GdL is 5-7 nm, and the numbers of GdL are 1.36x10(4) per Au NP. Au@GdL exhibits high longitudinal (r1) and transverse (r2) relaxivities of 1.87x10(5) and 3.02x10(5) mM(-1) s(-1), respectively. |
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