Lower prevalence of chromosome aberrations and SCEs in self-poisoned pregnant women |
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Authors: | T T Huong I Szentesi A Czeizel |
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Affiliation: | Department of Human Genetics and Teratology, National Institute of Hygiene, Budapest, Hungary. |
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Abstract: | A cytogenetic investigation was conducted in 18 self-poisoned pregnant and 16 self-poisoned non-pregnant women and in 31 pregnant and non-pregnant controls. Blood samples for analysis of chromosomal aberrations and SCEs were collected from women who were at different early stages of pregnancy. The difference between self-poisoned women and controls was very highly significant in the case of chromatid-type and unstable chromosome-type aberrations and highly significant in the case of SCEs. Further, the frequency of chromatid aberrations in pregnant women relative to non-pregnant ones was significantly lower suggesting a possible protective effect of pregnancy. |
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