Model misspecification in proportional hazards regression |
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Authors: | ANDERSON, GARNET L. FLEMING, THOMAS R. |
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Affiliation: | 1 Fred Hutchinson Cancer Research Center 1124 Columbia Street, Seattle, Washington 98104, U.S.A. 2 Department of Biostatistics, University of Washington Seattle, Washington 98195, U.S.A. |
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Abstract: | The proportional hazards model is frequently used to evaluatethe effect of treatment on failure time events in randomisedclinical trials. Concomitant variables are usually availableand may be considered for use in the primary analyses underthe assumption that incorporating them may reduce bias or improveefficiency. In this paper we consider two approaches to includingcovariate information: regression modelling and stratification.We focus on the setting where covariate effects are nonproportionaland we compare the bias, efficiency and coverage propertiesof these approaches. These results indicate that our intuitionbased on linear model analysis of covariance is misleading.Covariate adjustment in proportional hazards models has littleeffect on the variance but may significantly improve the accuracyof the treatment effect estimator. |
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Keywords: | Analysis of covariance Model misspecification Omitted covariates Proportional hazards |
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