Structure-activity relationship study of homoallylamines and related derivatives acting as antifungal agents |
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| Authors: | Suvire Fernando D Sortino Maximiliano Kouznetsov Vladimir V Vargas M Leonor Y Zacchino Susana A Cruz Uriel Mora Enriz Ricardo D |
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| Institution: | Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis (U.N.S.L.), Chacabuco 917, 5700 San Luis, Argentina. |
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| Abstract: | The synthesis, in vitro evaluation, and structure-activity relationship studies of homoallylamines and related derivatives acting as antifungal agents are reported. Among them, compounds N-(4-bromophenyl)-N-(2-furylmethyl)amine and N-(4-chlorophenyl)-N-(2-furylmethyl)amine reported here exhibited remarkable antifungal activity against dermatophytes. Theoretical calculations allow us to determine the minimal structural requirements to produce the antifungal response and can provide a guide for the design of compounds with these properties. |
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