Study of Salmonella endotoxin on the changes in lipid-protein interactions of membranes using Arrhenius plots of cetylcholinesterase as a tool |
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Authors: | M K Ray A Mitra B Mukherjee G C Chatterjee |
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Institution: | (1) Department of Biochemistry, University College of Science, 35, Ballygunge Circular Road, 700 019 Calcutta, India |
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Abstract: | Lipopolysaccharides ofSalmonella typhimurium inhibit the activity of acetylcholinesterasein vitro in both synaptosomal and erythrocyte membranes. Arrhenius plots show that the transition temperatures of membrane bound acetylcholinesterase
are significantly reduced in the presence of lipopolysaccharides, and the activation energies above and below transition temperature
have increased with the lowering of transition temperature. These results indicate that an alteration in the fluidity of the
phospholipid layer of the membranes, may be responsible for the membrane-specific effect of lipopoly-saccharides on acetylcholinesterase
activity. |
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Keywords: | Membrane acetylcholinesterase endotoxin transition temperature inhibition |
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