Biotransformation of p-, m-, and o-hydroxybenzoic acids by Panax ginseng hairy root cultures |
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Authors: | Xin Chen Jian Zhang Ji-Hua Liu Bo-Yang Yu |
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Abstract: | The regioselective glycosylation of three isomers of hydroxybenzoic acids was observed in Panax ginseng hairy root cultures. p-Hydroxybenzoic acid (1) and m-hydroxybenzoic acid (2) were converted into their corresponding glycosides (1a and 2a) and glycosyl esters (1b and 2b) while no metabolite of o-hydroxybenzoic acid (3) was detected. A new compound, m-hydroxybenzoic acid β-d-xylopyranosyl (1 → 6)-β-d-glycopyranosyl ester (2c) was identified as a biotransformation product of 2. Further time-course studies of the biotransformation reactions showed that the glycosides were major products in the latter stage. The addition of carbohydrates or antioxidants increased glycosyl esters formation. |
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Keywords: | Biotransformation Glycosylation Hydroxybenzoic acid Panax ginseng Hairy root cultures |
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