Analysis of the cps1 gene provides evidence for a septation checkpoint in Schizosaccharomyces pombe |
| |
Authors: | X. Le Goff A. Woollard V. Simanis |
| |
Affiliation: | Cell Cycle Control Laboratory Swiss Institute for Experimental Cancer Research (ISREC) Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland e-mail: viesturs.simanis@isrec.unil.ch Tel.: +41-21-6925888, Fax: +41-21-6526933, CH ICRF Cell Cycle Control Laboratory PO Box 123, London WC2A 3PX, UK, GB
|
| |
Abstract: | The fission yeast gene cps1, which encodes the catalytic subunit of β-glucan synthase, was isolated in a screen for mutants that show an increase in ploidy at the restrictive temperature. cps1 mutants display defects in both polarity and septation at the permissive temperature, and become swollen and multinucleate at the restrictive temperature. Analysis of the interaction of cps1 with other mutations suggests the existence of a septation checkpoint, which requires the activity of the protein kinase wee1 for function. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|