Polar head groups manipulation of phospholipids in cultured neuroblastoma cells |
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| Authors: | J Robert G Rebel P Mandel E Yavin |
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| Institution: | 1. Centre de Neurochimie du CNRS and Institut de Chimie Biologique, Faculté de Médecine, 11 rue Humann, 67085 Strasbourg Cedex, France;2. Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel |
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| Abstract: | The phospholipid polar head groups composition of neuroblastoma cells growing in surface cultures was altered as a result of ethanolamine and N-methyl ethanolamine base analogues addition. After 2 days incubation a significant increase of about 30% of the cellular phospholipids and the cholesterol content was evident. These changes were accompanied by a decrease in the cellular adhesive properties and the total cell number. The fatty acid profiles of the phosphoglycerides were practically identical irrespective of the base supplement. |
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