Myc-oncogene Inactivating Effect by Proline Rich Polypeptide (PRP-1) in Chondrosarcoma JJ012 Cells |
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Authors: | Galoian Karina Scully Sean Galoyan Armen |
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Institution: | (1) Department of Orthopedics, Miller School of Medicine, University of Miami, 1600 NW 10th Ave, Suite 8006 (r-2), Miami, FL 33136, USA;(2) Department of Orthopedics, Miller School of Medicine, University of Miami Hospital, 1400 NW 12 Ave, Suite 2, Miami, FL 33136, USA;(3) Institute of Biochemistry, National Academy of Sciences, 5/1 Paruir Sevak Str., Yerevan, 0014, Republic of Armenia |
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Abstract: | Proline rich polypeptide (PRP-1) produced by NPV and NSO cells is released into the general circulation and exerts its effect
on the activity of immunocompetent and neuronal cells. PRP-1 is a unique regulator of hematopoiesis, stimulator of bone-marrow
hematogenesis. Taking into consideration our preliminary data on antitumor and unique diverse biological properties of PRP-1
previously described by Galoyan et al., we proceeded with investigation of the PRP-1 effect on chondrosarcoma, the second
most common malignancy in bone, which tends to be locally invasive and then metastatic. Currently it does not have any effective
treatment and does not respond either to radiation or chemotherapy, leaving surgical resection as the only option. Our experimental
results of PRP-1 action on human chondrosarcoma JJ012 cells demonstrated inactivation, abolishment of Myc oncogene activity
usually upregulated in chondrosarcoma cells and other malignancies. The fact that addition of PRP-1 caused drastic inactivation
of Myc–luc response element to the control level in human chondrosarcoma JJ012 cell line prompts to investigate further this
neuropeptides powerful antioncogenic potential, opening up possibilities to consider PRP-1 as a potential therapeutic tool
for chondrosarcoma treatment. |
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Keywords: | Proline rich polypeptide Chondrosarcoma Myc oncogene Hypothalamic neuropeptides Cancer |
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