Specificity of chimpanzee antibodies binding a strain-specific HIV-1 neutralization epitope of the external envelope |
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Authors: | J Goudsmit M Bakker L Smit R H Meloen |
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Institution: | Human Retrovirus Laboratory, Academic Medical Center, Amsterdam, The Netherlands. |
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Abstract: | Sera from three chimpanzees infected with a primary lymphadenopathy-associated virus (LAV-1) or human T-lymphotropic virus type III (HTLV-IIIB) passage, from two chimpanzees infected with blood from the primary infected chimpanzees, and from one chimpanzee infected with blood from a secondary passage animal all bound the peptides 3B and 3B/RF, sharing the sequence IQRGPGR, with equally high titers. Pepscan analysis confirmed the amino acids Q, R, G, P, and G as irreplaceable in order to retain antigenicity. |
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Keywords: | Synthetic peptides Variable domain Peptide analogs HTLV-IIIB HTLV-IIIRF |
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