| 菟丝子提取物对活性氧引起已分化的PC12细胞损伤的保护作用 |
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| 引用本文： | 王利华 卜鹏程 包永明. 菟丝子提取物对活性氧引起已分化的PC12细胞损伤的保护作用[J]. 细胞生物学杂志, 2005, 27(1): 69-72 |
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| 作者姓名： | 王利华 卜鹏程 包永明 |
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| 作者单位： | 大连理工大学生物科学与工程系 大连116023(王利华，卜鹏程)，大连理工大学生物科学与工程系 大连116023(包永明) |
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| 摘 要： | 以常用的神经嗜铬细胞瘤PC12细胞株为实验模型，通过比较活性氧(ROS)作用细胞后的细胞活力、凋亡相关蛋白(p53、Bax)水平以及细胞中SOD、GSH、MDA的差异，发现菟丝子提取物不仅能提高ROS损伤的已分化PC12细胞活力，调节细胞中凋亡相关基因的表达，而且还能提高细胞中SOD和GSH的含量，降低MDA水平。由此表明，菟丝子提取物对ROS造成的PC12细胞损伤有一定的保护作用。
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| 关 键 词： | PC12细胞 ROS 菟丝子 保护作用 提取物 损伤 GSH 活性氧 分化 节细胞 |
| 修稿时间： | 2004-05-12 |
Neuroprotective Effect of Cuscuta chinensis Lam Extract on the Neuronal Differentiated PC12 Cells Damage Induced by Reactive Oxygen Species |
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| Li-Hua Wang,Peng-Cheng Bu,Yong-Ming Bao. Neuroprotective Effect of Cuscuta chinensis Lam Extract on the Neuronal Differentiated PC12 Cells Damage Induced by Reactive Oxygen Species[J]. Chinese Journal of Cell Biology, 2005, 27(1): 69-72 |
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| Authors: | Li-Hua Wang Peng-Cheng Bu Yong-Ming Bao |
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| Affiliation: | Li-Hua Wang,Peng-Cheng Bu,Yong-Ming Bao* |
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| Abstract: | The pharmacology and clinical application of traditional Chinese medicine has been extensivelydocumented. In the present study, with the comparison of the expression of apoptosis proteins p53, Bax and Bcl-2,and the level of superoxidase, glutathione, malondialdehyde of neuronal differentiated PC12 cells in the absence and/or presence of Cuscuta chinensis Lam extract, we found that Cuscuta chinensis Lam extract, in a dose-dependentmanner, prevents the neuronal differentiated PC12 cells damage from reactive oxygen species. |
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| Keywords: | Cuscuta chinensis Lam reactive oxygen species apoptosis |
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