Perspective: functional genomics towards new biotechnology in medicinal plants |
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Authors: | Mami Yamazaki Amit Rai Naoko Yoshimoto Kazuki Saito |
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Institution: | 1.Graduate School of Pharmaceutical Sciences,Chiba University,Chiba,Japan;2.RIKEN Center for Sustainable Resource Science,Yokohama,Japan |
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Abstract: | The secret of chemical diversity and function of specialized metabolites in medicinal plants will be unveiled by study of functional genomics at an unprecedentedly rapid rate in the coming years. This is mostly ascribed to the remarkable advancement in the high-throughput DNA sequencing together with other omics technologies such as metabolomics, in particular, due to drastic reduction in the cost of acquiring, storing and analyzing massive omics datasets. Once the genes involved in a biosynthetic pathway of specialized compounds in plants are elucidated, synthetic biology or genome editing can be applied to produce the target compounds in an engineered organism or to manipulate the pathway in planta. Coupled with these advancements in pathway elucidation approaches, modern plant biotechnology strategies are bound to significantly contribute to the sustainable development goals set by United Nations. |
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