| 肉瘤-180小鼠体液中抑癌因子的研究 |
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| 引用本文： | 周爱如,李玉琪,王新娟. 肉瘤-180小鼠体液中抑癌因子的研究[J]. 中国生物化学与分子生物学报, 1985, 1(2): 69-74 |
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| 作者姓名： | 周爱如 李玉琪 王新娟 |
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| 作者单位： | 北京医学院生物化学教研室(周爱如，李玉琪)，北京医学院生物化学教研室(王新娟) |
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| 基金项目： | 中国科学院科学基金生376号资助 |
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| 摘 要： | 本文报告从肉瘤-180小鼠腹水液中分离出抑癌因子,并将其与艾氏腹水瘤小鼠腹水中的抑癌因子进行比较。结果表明,二者具有相同的生物学特性和理化性质:1.它们均能杀伤不同的癌细胞株,但对正常细胞没有影响;2.经聚丙烯酰胺凝胶电泳,为泳动速率相同的均一多肽。
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| 关 键 词： | 抑癌因子 艾氏腹水癌 肉瘤-180 聚丙烯酰胺凝胶电泳 |
| 收稿时间： | 1985-04-20 |
A Cancer Suppressive Factor in Sarcoma-180 Mice |
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| Zhou Airu,Li Yuchi and Wang Xinjuan. A Cancer Suppressive Factor in Sarcoma-180 Mice[J]. Chinese Journal of Biochemistry and Molecular Biology, 1985, 1(2): 69-74 |
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| Authors: | Zhou Airu Li Yuchi Wang Xinjuan |
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| Affiliation: | Zhou Airu,Li Yuchi and Wang XinjuanDepartment of Biochemistry,Beijing Medical College |
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| Abstract: | A cancer suppressive factor (CSF) has been isolated from the ascites of Sarcoma-180 mice (S180). The peptide has been compared to the CSF of the ascites of Ehrlich Ascites Carcinoma (EAC) bearing mice. At 0.4mg/ml S180-CSF inhibited 92.1% of the growth of S180 cells and 74.4% of the growth of EAC cells respectively, whereas bone marrow cells are uninhibited. S180-CSF electrophoresed as a single band on polyacrylamide gel electrophoresis (PAGE). It displayed the same mobility as EAC-CSF. The results suggested that S180-CSF is similar to EAC-CSF in at least two important aspects. 1. It inhibits the growth of the two kinds of cancer cell lines whereas it has little affect on normal cells. 2. It is a single peptide exhibiting the same mobility on PAGE. |
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| Keywords: | Cancer Suppressive FactorEhrlich Ascites CarcinomaSarcoma-180Polyacrylamide Gel Electrophoresis |
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