Effects of serpasil on lipids,lipoprotein lipase and lipogenic enzymes in alloxan diabetic rats |
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| Authors: | Sarah Varghese K Saraswathy Devi |
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| Institution: | (1) Department of Biochemistry, University of Kerala, 695001 Trivandrum, India |
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| Abstract: | Diabetes intensifies the development of atherosclerosis. Treatment with antihypertensive drug, serpasil, arrested the progression
of atherosclerosis in alloxan diabetic rats by significantly decreasing the concentration of cholesterol, phospholipids and
triglycerides of serum, liver, kidney and aorta. Serpasil also decreased fasting blood sugar and urine sugar levels in these
rats. Serpasil administration remarkably altered the deranged lipid metabolism in alloxan diabetic rats by nearly restoring
the lipolytic and lipogenic enzyme activity to that of the normal |
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| Keywords: | Diabetes hypotensive agent serpasil lipoprotein lipase lipogenic enzymes |
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