Detection of non-coding RNAs on the basis of predicted secondary structure formation free energy change |
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| Authors: | Andrew V Uzilov Joshua M Keegan David H Mathews |
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| Institution: | (1) Department of Biochemistry & Biophysics, University of Rochester Medical Center, 601 Elmwood Avenue, Box 712, Rochester, New York 14642, USA;(2) Department of Biostatistics & Computational Biology, University of Rochester Medical Center, 601 Elmwood Avenue, Box 712, Rochester, New York 14642, USA;(3) Center for Pediatric Biomedical Research, University of Rochester Medical Center, 601 Elmwood Avenue, Box 712, Rochester, New York 14642, USA |
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| Abstract: | Background Non-coding RNAs (ncRNAs) have a multitude of roles in the cell, many of which remain to be discovered. However, it is difficult
to detect novel ncRNAs in biochemical screens. To advance biological knowledge, computational methods that can accurately
detect ncRNAs in sequenced genomes are therefore desirable. The increasing number of genomic sequences provides a rich dataset
for computational comparative sequence analysis and detection of novel ncRNAs. |
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