Synthesis and in vivo antihyperglycemic activity of 5-(1H-pyrazol-3-yl)methyl-1H-tetrazoles |
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| Authors: | Sharon Ashoke Pratap Ramendra Tiwari Priti Srivastava Arvind Maulik P R Ram Vishnu Ji |
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| Affiliation: | Division of Molecular and Structural Biology, Central Drug Research Institute, Lucknow 226001, India. |
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| Abstract: | A series of 5-[(5-aryl-1H-pyrazol-3-yl)methyl]-1H-tetrazoles 3a-h have been synthesized and evaluated for their in vivo antihyperglycemic activity. Some of the synthesized compounds have shown significant glucose lowering activity in male Sprague-Dawley rats in sucrose loaded model. These compounds were also evaluated for their peroxisome proliferator activated receptor gamma agonistic property, but none of them displayed any significant activity. |
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