Anencephaly in trisomy 18 associated with elevated alpha-1-fetoprotein in amniotic fluid |
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| Authors: | Ulrik Merrild Vibeke Schiøler Flemming Christensen Ewald Wolny Carl Johan Edeling |
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| Affiliation: | (1) Department of Medical Genetics, The John F. Kennedy Institute, Gl. Landevej 7, DK-2600 Glostrup, Denmark;(2) Department of Clinical Chemistry, Copenhagen County Hospital, Herlev, Denmark;(3) Department of Obstetrics and Gynaecology, Copenhagen County Hospital, Glostrup, Denmark;(4) Department of Nuclear Medicine, Rigshospitalet, Copenhagen, Denmark |
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| Abstract: | Summary Elevated levels of alpha-1-fetoprotein (AFP) were found in the amniotic fluid of a 36-year-old woman in the 15th week of gestation. Because of this and the results of repeated ultrasonography, abortion was induced. An anencephalic fetus with trisomy 18 was delivered. The possible correlation among neural-tube defects, chromosomal abnormalities, and level of AFP is discussed. |
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