Specific tyrosine phosphorylation in response to bile in Fasciola hepatica and Echinostoma friedi |
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Authors: | Marcilla Antonio Rubia José Enrique De la Espert Ana Carpena Inés Esteban José Guillermo Toledo Rafael |
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Institution: | Departamento de Parasitología y Biología Celular, Facultad de Farmacia, Universidad de Valencia, Av. Vicent Andrés Estellés s/n, 46100 Burjassot, Valencia, Spain. antonio.marcilla@uv.es |
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Abstract: | Protein tyrosine phosphorylation (PY) is a well-known signalling mechanism which is also involved in host-parasite interactions. Despite its transcendence, PY has been poorly studied in parasitic helminths. The aim of this study is to examine the effect of bile salts on the PY pattern in parasitic trematodes. Two distinct adult models were analysed: Echinostoma friedi, of intestinal habitat, and Fasciola hepatica, naturally inhabitant of host biliary channels. Our results show that bile salts induce specific and distinct protein PY in both trematode species, indicating that this signalling process seems to be also involved in host-trematode relationships. |
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