Support of embryonic chick survival by vitamin D metabolites |
| |
| Authors: | S Ameenuddin M L Sunde H F DeLuca N Ikekawa Y Kobayashi |
| |
| Institution: | 1. Departments of Biochemistry and Poultry Science, College of Agricultural and Life Sciences, University of Wisconsin-Madison, Madison, Wisconsin 53706 USA;2. Department of Chemistry, Tokyo Institute of Technology, Ookayama, Meguro-ku, Tokyo, Japan;3. Faculty of Pharmaceutical Sciences, Teikyo University, Sagamiko, Kanagawa, Japan |
| |
| Abstract: | The provision of 1,25-dihydroxyvitamin D3 as the only source of dietary vitamin D3 to laying hens failed to support normal embryonic development in their fertile eggs. Significant (P less than .001) improvement in embryonic survival to hatching in these eggs resulted from injections of 1,25-dihydroxyvitamin D3, 24,25-dihydroxyvitamin D3, 25-hydroxyvitamin D3, or 24,24-difluoro-25-hydroxyvitamin D3 prior to incubation. Maximum embryonic survival with lowest embryonic mortality was observed when 0.20 micrograms/egg of 1,25-dihydroxyvitamin D3 or 0.60 micrograms/egg 25-hydroxyvitamin D3 was injected. These results indicate that several forms of vitamin D, two of which cannot be converted to 24,25-dihydroxyvitamin D3, can provide this activity; and of the vitamin D compounds tested, 1,25-dihydroxyvitamin D3 may be the most active in supporting embryonic survival in the chick when delivered directly by injection. |
| |
| Keywords: | To whom correspondence should be addressed |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
