| 一组多功能的错配修复蛋白 |
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| 引用本文： | 禄婷婷,徐克前.一组多功能的错配修复蛋白[J].生命的化学,2008,28(6). |
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| 作者姓名： | 禄婷婷 徐克前 |
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| 作者单位： | 中南大学湘雅医学院检验系,长沙,410013 |
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| 摘 要： | 错配修复蛋白是DNA错配修复系统中主要功能蛋白质,主要参与DNA复制过程中对错配碱基的识别和修复.近年来研究表明错配修复蛋白还参与DNA损伤信号的传递、细胞周期的调控、减数分裂和有丝分裂等.错配修复蛋白缺陷会增加患肿瘤的危险性或者直接导致肿瘤;由于错配修复蛋白参与了DNA损伤信号传递、周期调控,错配修复蛋白缺陷还会导致细胞对相关抗癌药物产生耐受.
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| 关 键 词： | 错配修复蛋白 DNA错配修复系统 肿瘤 |
The multifunction of mismatch repair protein |
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| Ting-Ting LU,Ke-Qian XU.The multifunction of mismatch repair protein[J].Chemistry of Life,2008,28(6). |
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| Authors: | Ting-Ting LU Ke-Qian XU |
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| Institution: | Ting-Ting LU Ke-Qian XU (Department of Clinical Laboratory Medicine of Xiangya School,Central South University,Changsha 410013,China) |
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| Abstract: | DNA mismatch repair protein is the main functional protein in DNA mismatch repair (MMR), which is primarily involved in the recognition and repair of specific types of errors that occur during new DNA synthesis. DNA mismatch repair protein also functions in DNA-damage signaling, the regulation of cell cycle, meiosis and mitosis. Mismatch repair protein deficiencies will increase the risk of suffering from cancer or directly lead to tumor. Because it is involved in DNA-damage signaling, mismatch repair prote... |
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| Keywords: | mismatch repair protein DNA mismatch repair tumor |
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