Isolation and characterization of a variant form of vasoactive intestinal polypeptide |
| |
| Authors: | G Gafvelin M Andersson R Dimaline H J?rnvall V Mutt |
| |
| Affiliation: | Department of Biochemistry II and Chemistry I, Karolinska Institute, Stockholm, Sweden. |
| |
| Abstract: | A variant form of the vasoactive intestinal polypeptide (VIP) has been isolated. It was found to consist of a molecule which instead of the C-terminal asparagine amide of VIP has a C-terminal extension of Gly-Lys-Arg. This VIP variant displaces VIP in a VIP receptor assay, reacts with N-terminally-directed antisera in a VIP radioimmunoassay and possesses VIP-like bioactivity in an assay measuring pancreatic juice secretion in the cat. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
