Dammarane-type glycosides from Gynostemma pubescens |
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Authors: | Yang Zhengyi Chen Qiuqun Hu Lihong |
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Institution: | Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 199 Guoshoujing Road, Shanghai 201203, PR China. |
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Abstract: | Triterpene saponins 1-8 were isolated from the aerial parts of Gynostemma pubescens. Among them, compounds 1-4, 8 possess carboxylic groups at both C-21 and C-29, 5 contains a carboxylic group at C-21 and an aldehyde function at C-29, whereas 6 and 7 contain carboxylic groups at C-21 and hydroxymethylene groups at C-29. Their structural elucidation was accomplished by extensive spectroscopic methods including application of 1D (1H, (13)C, (13)C DEPT) and 2D NMR experiments (HMQC, HMBC, HSQC), HRESIMS analysis, as well as by chemical degradation. |
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