Control of actin assembly and disassembly at filament ends |
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Authors: | Cooper J A Schafer D A |
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Affiliation: | Department of Cell Biology, Washington University, Box 8228, St Louis, MO 631110, USA. jcooper@cellbio.wustl.edu |
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Abstract: | The most important discovery in the field is that the Arp2/3 complex nucleates assembly of actin filaments with free barbed ends. Arp2/3 also binds the sides of actin filaments to create a branched network. Arp2/3's nucleation activity is stimulated by WASP family proteins, some of which mediate signaling from small G-proteins. Listeria movement caused by actin polymerization can be reconstituted in vitro using purified proteins: Arp2/3 complex, capping protein, actin depolymerizing factor/cofilin, and actin. actin depolymerizing factor/cofilin increases the rate at which actin subunits leave pointed ends, and capping protein caps barbed ends. |
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