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Antimicrobial activity of aqueous extracts of Larrea divaricata Cav (jarilla) against Helicobacter pylori |
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| Authors: | PW Stege RC Davicino AE Vega YA Casali S Correa B Micalizzi |
| Institution: | aArea Microbiología, Departamento de Bioquímica y Ciencias Biológicas, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis. Chacabuco y Pedernera, 5700, San Luis, Argentina bArea bromatología y Ensayo y Valoración de Medicamentos, Departamento de Farmacia, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis. Chacabuco y Pedernera, 5700, San Luis, Argentina cInmunologia, CIBICI (CONICET) Departamento de Bioquímica Clínica, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria, 5000 Córdoba, Argentina |
| Abstract: | We studied here the effect of aqueous extracts of Larrea divaricata Cav on the growth of Helicobacter pylori. Results show that cold extract, infusion, decoction and simulated digestion had inhibitory activity at 0.04–0.1 mg/l against clarithromycin and metronidazole susceptible and resistant H. pylori strains. These results support the popular use of L. divaricata Cav in gastric disturbances and prompt further research to characterize these compounds with a therapeutic potential against gastric ulcers and gastric cancer associated with H. pylori. |
| Keywords: | Larrea divaricata Cav extracts Helicobacter pylori Antimicrobial activity |
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