Chemical engineering of mesenchymal stem cells to induce a cell rolling response |
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Authors: | Sarkar Debanjan Vemula Praveen Kumar Teo Grace S L Spelke Dawn Karnik Rohit Wee Le Y Karp Jeffrey M |
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Affiliation: | Department of Medicine, Harvard-MIT Division of Heath Sciences and Technology, Brigham and Women's Hospital, Harvard Medical School, Cambridge, Massachusetts 02139, USA. |
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Abstract: | Covalently conjugated sialyl Lewis X (SLeX) on the mesenchymal stem cell (MSC) surface through a biotin-streptavidin bridge imparts leukocyte-like rolling characteristics without altering the cell phenotype and the multilineage differentiation potential. We demonstrate that the conjugation of SLeX on the MSC surface is stable, versatile, and induces a robust rolling response on P-selectin coated substrates. These results indicate the potential to increase the targeting efficiency of any cell type to specific tissue. |
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