Characterization of ursolic acid as a lipoxygenase and cyclooxygenase inhibitor using macrophages, platelets and differentiated HL60 leukemic cells. |
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| Authors: | A Najid A Simon J Cook H Chable-Rabinovitch C Delage A J Chulia M Rigaud |
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| Affiliation: | CJF INSERM 88-03, Faculté de Médecine, Université de Limoges, France. |
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| Abstract: | A new property of ursolic acid, lipoxygenase and cyclooxygenase inhibition, has been described in an acetone-extract of heather flowers (Calluna vulgaris) which could help explain the anti-inflammatory characteristics of this plant. In mouse peritoneal macrophages, human platelets and differentiated HL60 leukemic cells, ursolic acid, at 1 microM, blocks arachidonate metabolism. |
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