Retinoid X receptor and peroxisome proliferator-activated receptor-gamma agonists cooperate to inhibit matrix metalloproteinase gene expression |
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| Authors: | Peter S Burrage Adam C Schmucker Yanqing Ren Michael B Sporn Constance E Brinckerhoff |
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| Institution: | (1) Department of Biochemistry, Dartmouth Medical School, North College Street, 7200 Vail Building, Hanover, NH 03755, USA;(2) Department of Pharmacology, Dartmouth Medical School, North College Street, 7650 Remsen Hall, Hanover, NH 03755, USA;(3) Department of Medicine, Dartmouth Medical School, 1 Medical Center Drive, Lebanon, NH 03756, USA |
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| Abstract: | Introduction We recently described the ability of retinoid X receptor (RXR) ligand LG100268 (LG268) to inhibit interleukin-1-beta (IL-1-β)-driven
matrix metalloproteinase-1 (MMP-1) and MMP-13 gene expression in SW-1353 chondrosarcoma cells. Other investigators have demonstrated similar effects in chondrocytes treated
with rosiglitazone, a ligand for peroxisome proliferator-activated receptor-gamma (PPARγ), for which RXR is an obligate dimerization
partner. The goals of this study were to evaluate the inhibition of IL-1-β-induced expression of MMP-1 and MMP-13 by combinatorial treatment with RXR and PPARγ ligands and to investigate the molecular mechanisms of this inhibition. |
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