Ethanol-induced analgesia |
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| Authors: | L A Pohorecky P Shah |
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| Affiliation: | 1. Department of Chemistry, Faculty of Science, University of Guilan, Rasht, Iran;2. Department of Engineering, East of Guilan, University of Guilan, Rudsar, Iran;1. Departamento de Neuroquímica, Subdirección de Investigaciones Clínicas, Instituto Nacional de Psiquiatría Ramón de la Fuente, Ciudad de México, México;2. Laboratorio de Psicología Experimental, Instituto de Investigaciones Psicológicas (IIPsi - CONCET - UNC), Facultad de Psicología, Universidad Nacional de Córdoba, Córdoba, Argentina;1. Materials Center Leoben Forschung GmbH, Roseggerstraße 12, 8700 Leoben, Austria;2. Montanuniversität Leoben, Institut für Struktur- und Funktionskeramik (ISFK), Peter-Tunner Straße 5, 8700 Leoben, Austria;3. Ceratizit Austria GmbH, Metallwerk-Plansee-Straße 71, 6600 Reutte, Austria |
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| Abstract: | The effect of ethanol (ET) on nociceptive sensitivity was evaluated using a new tail deflection response (TDR) method. The IP injection of ET (0.5-1.5 g/kg) produced rapid dose-dependent analgesia. Near maximal effect (97% decrease in TDR) was produced with the 1.5 g/kg dose of ET ten minutes after injection. At ninety minutes post-injection there was still significant analgesia. Depression of ET-induced nociceptive sensitivity was partially reversed by a 1 mg/kg dose of naloxone. On the other hand, morphine (0.5 or 5.0 mg/kg IP) did not modify ET-induced analgesia, while 3.0 minutes of cold water swim (known to produce non-opioid mediated analgesia) potentiated ET-induced analgesic effect. The 0.5 g/kg dose of ET by itself did not depress motor activity in an open field test, but prevented partially the depression in motor activity produced by cold water swim (CWS). Thus the potentiation by ET of the depression of the TDR produced by CWS cannot be ascribed to the depressant effects of ET on motor activity. |
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