Actions of endothelin-1 on prostaglandin production by gestational tissues |
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Authors: | M D Mitchell R J Romero R Lepera L Rittenhouse and S S Edwin |
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Abstract: | Endothelin-1 (10−11M-10−7M) was incubated with human umbilical vein endothelial cells and cells derived from amnion and decidua and prostaglandin production was determined. The rates of biosynthesis of 6-keto-prostaglandin F1 (6-keto-PGF1 ) and prostaglandin E2 (PGE2) by endothelial cells were increased significantly by treatment with endothelin-1. Amnion cell PGE2 production was reduced significantly by endothelin-1 treatment whereas decidual PGE2 and prostaglandin F2 production was unaffected by this treatment. Thus, it is possible that endothelins may play a part in the regulation of uteroplacental hemodynamics and the mechanisms of parturition. |
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