Inhibition of IFN-gamma-inducible protein-10 abrogates colitis in IL-10-/- mice |
| |
Authors: | Singh Udai P Singh Shailesh Taub Dennis D Lillard James W |
| |
Affiliation: | Department of Microbiology and Immunology, Morehouse School of Medicine, Atlanta, GA 30310, USA. |
| |
Abstract: | A deficiency in understanding the steps responsible for colitis is the lack of comprehension for the role chemokines play in mucosal inflammation. IFN-gamma-inducible protein-10 (IP-10) and CXCR3 are highly expressed at sites of colitis. Our findings show that IP-10 significantly contributes to the development of Th1 and inflammatory responses. Specifically, IP-10 inhibition in IL-10(-/-) mice attenuates the associated increases in serum and/or local amyloid A, IL-2, IL-6, TNF-alpha, IFN-gamma, IL-1alpha, and IL-1beta with colitis as compared with IL-10(-/-) mice that develop colitis similar to human Crohn's disease. Correspondingly, the rate or intensity of inflammation in IL-10(-/-) mice treated with anti-IP-10 Abs showed improved scoring of inflammation, compared with control IL-10(-/-) mice. This study provides important and novel information regarding IP-10 as a target for the treatment of colitis. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|