A Common variant near the melanocortin 4 receptor is associated with low-density lipoprotein cholesterol and total cholesterol in the Chinese Han population |
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| Authors: | Liming Tao Zhou Zhang Zhuo Chen Daizhan Zhou Weidong Li Mengyuan Kan Di Zhang Lin He Guoying Huang Yun Liu |
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| Institution: | (1) Graduate School of the Chinese Academy of Sciences, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People’s Republic of China;(2) Key Laboratory of Developmental Genetics and Neuropsychiatric Diseases (Ministry of Education), Bio-X Center, Shanghai Jiao Tong University, Shanghai, 200030, People’s Republic of China;(3) Children’s Hospital, Fudan University, 399 Wan Yuan Road, Shanghai, 201102, People’s Republic of China;(4) Institutes of Biomedical Sciences, Fudan University, 303 Mingdao Building, 138 Yixueyuan Road, Shanghai, 200032, People’s Republic of China |
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| Abstract: | A number of recent genome-wide association studies in European populations have reported that variant rs17782313 is significantly
associated with obesity and body mass index (BMI). The purpose of the present study was to evaluate the association of rs17782313
with obesity and BMI in the Chinese Han population. We also sought to extend previous studies by determining whether this
SNP is associated with plasma lipid levels in the Chinese Han population. Rs17782313 was genotyped in two independent Chinese
Han cohorts (Cohort1: n = 2533; Cohort2: n = 2105). In our study, rs17782313 did not show significant association with either obesity or BMI in the Chinese Han population,
but showed evidence for association with LDL-C (P ~ 0.003) and TC (P ~ 0.001). Our findings indicate that the variant rs17782313 near MC4R is likely to have an impact on plasma lipid levels
of LDL-C and TC in the Chinese Han population. |
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