Human male gamete endocrinology: 1alpha, 25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates different aspects of human sperm biology and metabolism |
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| Authors: | Saveria Aquila Carmela Guido Emilia Middea Ida Perrotta Rosalinda Bruno Michele Pellegrino Sebastiano Andò |
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| Affiliation: | (1) Dept Pharmaco-Biology, University of Calabria 87036 Arcavacata di Rende (Cosenza), Italy;(2) Centro Sanitario, University of Calabria 87036 Arcavacata di Rende (Cosenza), Italy;(3) Dept Cellular Biology, University of Calabria 87036 Arcavacata di Rende (Cosenza), Italy;(4) Faculty of Pharmacy, University of Calabria 87036 Arcavacata di Rende (Cosenza), Italy |
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| Abstract: | Background A wider biological role of 1alpha,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D3, in tissues not primarily related to mineral metabolism was suggested. Recently, we evidenced the ultrastructural localization the 1,25(OH)2D3 receptor in the human sperm. However, the 1,25(OH)2D3 action in human male reproduction has not yet been clarified. |
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