Sleeping to fuel the immune system: mammalian sleep and resistance to parasites |
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Authors: | Mark R Opp |
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Institution: | (1) Departments of Anesthesiology and Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA |
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Abstract: | Sleep is an enigma. Why animals forgo eating and reproducing, while potentially increasing their risk of predation remains
unknown. Although some may question whether all animals sleep, it is clear that all living organisms possess defenses against
attack by pathogens. Immune responses of humans and animals are impaired by sleep loss, and responses to immune challenge
include altered sleep. Thus, sleep is hypothesized to be a component of the acute phase response to infection and to function
in host defense. Examining phylogenetic relationships among sleep parameters, components of the mammalian immune system and
resistance to infection may provide insight into the evolution of sleep and lead to a greater appreciation for the role of
sleep in host defense. |
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Keywords: | |
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