Stem cell therapy in inflammatory bowel disease: A promising therapeutic strategy? |
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引用本文: | Ana I Flores,Gonzalo J Gómez-Gómez,ángeles Masedo-González,M Pilar Martínez-Montiel.Stem cell therapy in inflammatory bowel disease: A promising therapeutic strategy?[J].World journal of stem cells,2015,7(2):343-351. |
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作者姓名: | Ana I Flores Gonzalo J Gómez-Gómez ángeles Masedo-González M Pilar Martínez-Montiel |
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作者单位: | Servicio de Aparato Digestivo,Hospital 12 de Octubre,Avda. de Córdoba,28041 Madrid,Spain |
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摘 要: | Inflammatory bowel diseases are inflammatory, chronic and progressive diseases of the intestinal tract for which no curative treatment is available. Research in other fields with stem cells of different sources and with immunoregulatory cells(regulatory T-lymphocytes and dendritic T-cells) opens up new expectations for their use in these diseases. The goal for stem cell-based therapy is to provide a permanent cure. To achieve this, it will be necessary to obtain a cellular product, original or genetically modified, that has a high migration capacity and homes into the intestine, has high survival after transplantation, regulates the immune reaction while not being visible to the patient’s immune system, and repairs the injured tissue.
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关 键 词: | Mesenchymal stem cell Hematopoietic stem cell Inflammatory bowel disease Crohn’s disease Ulcerative colitis Amniotic fluid stem cells Induced pluripotent stem cells Intestinal stem cells Endothelial progenitor cells Tolerogenic immune cell therapies |
收稿时间: | 2014 Jul 29 |
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