结核分枝杆菌基因组学与基因组进化

在后基因组时代,特别是在新的测序理论和设备大发展的背景下,一些重大传染性致病微生物基因组序列正在被逐一测定,并且随后的基因功能注释,蛋白质三维结构重建等工作也正在开展,以期对致病微生物的生物学特性、诊断策略和治疗方法等有突破性的认识.作为对人类健康一直存在严重威胁的结核分枝杆菌,其基因组在进化中所发生的各种遗传事件对其生物学性质、致病能力和抗药性等各方面有重要作用.本文旨在阐述结核分枝杆菌的起源及其基因组特征,论述其基因组进化的研究进展.

Genomics and Genome Evolution of Mycobacterium tuberculosis

The endless emergence of new theories and scientific instruments aiming to genome sequencing boosts the large ship of history advance of biology in the post-genomic era.With the genome sequences of major infectious disease-causing microorganisms being determined one by one,the subsequent annotation of gene function and the reconstruction work about protein functions are being carried out.All the efforts are to get a breakthrough understanding of biological characteristics,diagnostic strategies and treatment methods of pathogenic microorganisms.Mycobacterium tuberculosis has been a serious threat to human health globally.All genetic events occurring in the genome evolution play an important role in all aspects such as M.tuberculosis’s biological properties,pathogenicity and drug resistance.This review will summarize the origins and genomic features of M.tuberculosis,and discuss the current progress about its genome evolution.