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Synthesis of novel neutrophil-specific imaging agents for Positron Emission Tomography (PET) imaging

Authors:	Zhang Yi Kundu Bijoy Fairchild Karen D Locke Landon Berr Stuart S Linden Joel Pan Dongfeng

Institution:	^aDepartment of Radiology, The University of Virginia, 409 Lane Road, MR4 Building 1192, PO Box 801339, Charlottesville, VA 22908, USA ^bDepartment of Pediatrics, The University of Virginia, Charlottesville, VA 22908, USA ^cDepartment of Medicine, The University of Virginia, Charlottesville, VA 22908, USA

Abstract:	A neutrophil-specific peptide, cinnamoyl-F(D)LF(D)LFK (cFLFLFK), was conjugated consecutively with a polyethylene glycol moiety (3.4 K) and 2,2′,2″,2-(1,4,7,10-tetraazacyclododecane-1,4,7,10-tetrayl)tetraacetic acid (DOTA) to form cFLFLFK-PEG-DOTA. After ⁶⁴Cu labeling, Positron Emission Tomography (PET) imaging was successfully able to detect mouse lung inflammation.

Keywords:	Neutrophil antagonist Peptide tracer Inflammation imaging ⁶⁴Cu
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