| P物质对大鼠分离的DRG细胞GABA激活电流的抑制作用 |
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| 引用本文： | 吴晓平,李之望.P物质对大鼠分离的DRG细胞GABA激活电流的抑制作用[J].生理学报,1994,46(6):586-590. |
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| 作者姓名： | 吴晓平 李之望 |
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| 作者单位： | 同济医科大学实验医学研究中心 |
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| 摘 要： | 本文就用全细胞膜片箝技术，在新鲜分离的大鼠ＤＲＧ细胞上证明，在部分细胞Ｐ物质（１０＾－７－１０＾－５ｍｏｌ／Ｌ）可引起浓度依赖性的内向流（４／２６）；在多数细胞虽未检测到ＳＰ引起的膜电流，但却能对ＧＡＢＡＡ受体激活介导的膜内向流产生抑制效应（１８／２２），并有加速去敏感的作用。本文就有关ＳＰ以ＧＡＢＡ激活电流抑制效应的可能意义进行了讨论。
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| 关 键 词： | P物质 γ氨基丁酸 背根神经节细胞 |
INHIBITORY EFFECT OF SP ON GABA-ACTIVATED CURRENTS IN FRESHLY ISOLATED RAT DRG NEURONS |
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| WU XIAO-PING,LI ZHI-WANG AND FAN YOU-ZHEN.INHIBITORY EFFECT OF SP ON GABA-ACTIVATED CURRENTS IN FRESHLY ISOLATED RAT DRG NEURONS[J].Acta Physiologica Sinica,1994,46(6):586-590. |
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| Authors: | WU XIAO-PING LI ZHI-WANG AND FAN YOU-ZHEN |
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| Abstract: | The whole-cell patch-clamp technique was used to record GABA-activated currents in freshly isolated DRG neurons.It was found that application of SP (10-10(-5)mol/L)could induce concentration dependent inward currents in some cells (4/26),while no such current was detectable in the other neurons.However, preapplication of SP could inhibit the inward currents mediated by GABA& receptor(18/22).The inhibitory effect of SP was concentration dependent and reversible,and the desensitization of GABA-activated current could also be enhanced by SP. |
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