Estrogen regulates CCR gene expression and function in T lymphocytes |
| |
Authors: | Mo RuRan Chen Jun Grolleau-Julius Annabelle Murphy Hedwig S Richardson Bruce C Yung Raymond L |
| |
Affiliation: | Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. |
| |
Abstract: | Estrogen has been implicated in the observed female bias in autoimmune diseases. However, the mechanisms behind this gender dimorphism are poorly defined. We have previously reported that in vivo T cell trafficking is gender- and estrogen-dependent. Chemokine receptors are critical determinants of T cell homing and immune response. In this study, we show that the female gender is associated with increased CD4(+) T cell CCR1-CCR5 gene and protein expression in mice. The increased CCR expression correlates with enhanced in vitro chemotaxis response to MIP-1beta (CCL4). In vivo treatment of young oophorectomized and postmenopausal female mice with 17beta-estradiol also increased CD4(+) T cell CCR expression. Finally, 17beta-estradiol enhances tyrosine phosphorylation in T cells stimulated with MIP-1alpha in a time-dependent manner. Our results indicate an important role of estrogen in determining T cell chemokine response that may help explain the increased susceptibility and severity of autoimmune diseases in females. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|